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您现在的位置: 首页 > 细胞生物 > 干细胞生长分化因子 > Animal-Free Recombinant Human /Murine/Rat Activin A (E.coli derived)动物免疫重组人/鼠(大肠杆菌来源)

Animal-Free Recombinant Human /Murine/Rat Activin A (E.coli derived)动物免疫重组人/鼠(大肠杆菌来源)

Animal-Free Recombinant Human /Murine/Rat Activin A (E.coli derived)动物免疫重组人/鼠(大肠杆菌来源)
  • Animal-Free Recombinant Human /Murine/Rat Activin A (E.coli derived)动物免疫重组人/鼠(大肠杆菌来源)
英文名称: Animal-Free Recombinant Human /Murine/Rat Activin A (E.coli derived)
产品应用: 动物免疫重组人/鼠(大肠杆菌来源)
中国俗称: 人Activin-A 中国简称: Human Activin-A
注册品牌: PeproTech 生产厂家: 美国PeproTech
订购货号: AF-120-14E
规格型号: 2ug/10ug/50ug/100ug/500ug/1mg
保存温度: 2~8℃
产品种类: 重组细胞因子
到货时间: 现货1~5天
产品编码: YS0001118
市场价格: ¥0元
本店售价: ¥0元
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购买数量: 单价单位

产品描述

产品中文名称:Animal-Free Recombinant Human /Murine/Rat Activin A (E.coli derived)

产品英文名称:动物免疫重组人/鼠(大肠杆菌来源)

订购货号:Catalog Number:AF-120-14E

Synonyms:
Inhibin beta-1, FRP, FSH (Follicle-stimulating hormone)-releasing protein
 
Animal-Free Recombinant Human /Murine/Rat Activin A (E.coli derived)的详细说明:
        激活素A是TGF-β家族成员表现出广泛的生物学活性,包括细胞增殖和分化,并促进神经元存活的调节。激活素A在人结肠直肠肿瘤和绝经后妇女的水平升高有牵连在大肠癌和乳腺癌,分别。活化素A的生物活性可以通过抑制素和由扩散型TGF-β拮抗剂,卵泡抑素被中和。激活素A结合两种形式素受体I型(RI法-A和法RI-B)和两种形式素受体II型(RII法-A和法RII-B)的。激活素是同型二聚体或不同β亚基的异源二聚体。它们产生作为前体蛋白与被裂解以释放C-末端的生物活性配体的氨基末端前肽。人/小鼠/大鼠活化素A是二βA链,每片含116个氨基酸残基的一个26.0 kDa的二硫键连接的同型二聚体。
 
详细介绍:
        Activin A is a TGF-β family member that exhibits a wide range of biological activities, including regulation of cellular proliferation and differentiation, and promotion of neuronal survival.  Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively.  The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin.  Activin A binds to the two forms of activin receptor type I (Act RI-A and Act RI-B) and two forms of activin receptor type II (Act RII-A and Act RII-B).  Activins are homodimers or heterodimers of different β subunits.  They are produced as precursor proteins with an amino terminal propeptide that is cleaved to release the C-terminal bioactive ligand.  Human/Murine/Rat Activin A is a 26.0 kDa disulfide-linked homodimer of two βA chains, each containing 116 amino acid residues. Manufactured using all Animal-Free reagents.
 
AA Sequence:
GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS
 
来源Source:E.coli
 
Purity:
Greater than 97% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by its ability to inhibit the proliferation of mouse MPC-11 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
 
Cross Reactivity:
Chicken, Dog, Frog, Mouse, Human + Mouse, Human, Rat
 

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