产品英文名称：RetroNectin® Recombinant Human Fibronectin Fragment
RetroNectin® 重组人纤粘连蛋白 T100B产品简介：
RetroNectin® 重组人纤粘连蛋白 T100B产品英文描述：
RetroNectin Reagent—Recombinant Human Fibronectin
Research using hematopoietic cells and other suspension cells has been limited in part by low efficiency of gene transfer (transduction and transfection) into these cell types. RetroNectin reagent promotes co-localization of lentivirus or retrovirus with target cells to dramatically enhance transduction efficiency. As a consequence, RetroNectin reagent is now the gold standard transduction enhancer for retroviral/lentiviral gene transfer to hematopoietic cells and holds great promise in clinical application, having been used in over 40 clinical trials.
RetroNectin reagent has been widely used to enhance retroviral and lentiviral gene transfer method into mammalian cells.
In addition, RetroNectin reagent enhances the proliferation of T lymphocytes. T cells are conventionally expanded in the presence of Interleukin-2 (IL-2) by stimulation with anti-CD3 antibody. The addition of RetroNectin in this stimulation step dramatically increases the efficiency of T cell expansion. In addition, T cells expanded with this method contain a high proportion of less-differentiated T cells (naive T cells). Naive T cells have the ability to differentiate into cytotoxic T cells in vivo.
Enhanced gene transfer efficiency for retroviral or lentiviral transduction of suspension cells, hematopoietic stem cells, and other hard-to-infect cell types
Less toxicity than other commonly used transduction-enhancers, including polybrene and protamine
Fully recombinant peptide
Clinical grade RetroNectin (GMP) can be used for ex vivo clinical applications (investigational use only) - for GMP grade only please complete and return this form prior to purchase
Sterile solution containing 12.5 mM sodium citrate (pH6.2) and 1.25% sucrose
E. coli expressing human fibronectin fragment CH-296
Molecular weight :
62,617 Da (determined from amino acid sequence)
Storage : -20℃
Purity : > 90% by HPLC
RetroNectin® 重组人纤粘连蛋白 T100B相关产品订购信息：
Cat. # Product Size
T100B RetroNectin® Recombinant Human Fibronectin Fragment 2.5 mg
T110A RetroNectin® Precoated Dish 10 Dishes
T100A RetroNectin® Recombinant Human Fibronectin Fragment 0.5 mg
T201 RetroNectin® (GMP) 2.5 mg